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apalutamide will decrease the level or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medication that are CYP3A4 substrates may lead to lower exposure to those prescription drugs.Modafinil may be habit-forming. Under no circum

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